erable to compression of the vein alone.

The reason for this is not far to seek. When we compress the veins
alone there is a rapid accumulation of blood in the extremities
through the accessions derived from the uninterrupted arteries. Now,
as this blood is derived from the trunk, and consequently also from
the organs contained within the cerebro-spinal canal, there is danger
of syncope and even heart failure. When, on the other hand, both
artery and vein are compressed no such derivative action occurs, and
all danger is, consequently, removed. With an apology for this brief
digression, I now return to the interesting case which has given rise
to it.

Having, as previously stated, applied tourniquets to the central
portion of the lower limbs, the ether cap was placed over the mouth
and nose of the patient, and in an incredibly short time he was
unconscious, and the surgeons were able to go on with the operation.

The late Dr. Cornelius R. Agnew and many other members of the staff of
the hospital were present, and gave emphatic expressions of approval.

Dr. F.W. Ring, assistant surgeon to the Manhattan Eye and Ear
Hospital, declared that both the amount of ether and the time consumed
in its administration were infinitesimal when compared with what had
been expended in previous efforts at inducing anaesthesia in the usual
way. The facts brought out on this occasion with regard to the
administration of ether have since been repeatedly verified by
different observers; so that at the present day their validity cannot
be questioned. I will merely add, however, that I have long known that
the dosage of phenacetin, antipyrine, morphine, chloralamid, chloral,
the bromides, and many other remedies might be reduced by resort to
the same procedure; all of which is merely equivalent to stating that
their pharmaco-dynamic energy may be increased in this way. And this
brings us to the second fact, which requires no special elaboration,
and may be stated thus:

_Second Fact._--The duration of the effect of a remedy upon the
cerebro-spinal axis is in the inverse ratio of its volatility; and
this is equally true whether the remedy be given with or without the
precautions previously detailed. For example, the anaesthetic effects
of ether disappear shortly after removal of the inhaler, whether we
apply tourniquets to the extremities or not; but, on the other hand,
the analgesic influence of antipyrin, phenacetin, morphine, and other