nx of the first or last toe. The disease is dependent upon
impairment or degeneration of the central, truncal or peripheral nerves.

#What is to be said in regard to the prognosis and treatment?#

Treatment, which is, as a rule, unsatisfactory, consists in the
maintenance of absolute rest, and the use of antiseptic and stimulating
applications. Amputation is also resorted to, but even this is at times
futile, as a new sinus may appear upon the stump.

#Syphilis Cutanea.#
(_Synonyms:_ Syphiloderma; Dermatosyphilis; Syphilis of the Skin.)

#In what various types may syphilis manifest itself upon the integument?#

Syphilis may show itself as a macular, papular (rarely vesicular),
pustular, bullous, tubercular and gummatous eruption; or the eruption
may be, in a measure, of a mixed type.

#In what respects do the early (or secondary) eruptions of syphilis
differ from those following several years or more after the contraction
of the disease?#

The early or secondary eruptions are more or less generalized, with
rarely any attempt at special configuration. Their appearance is often
preceded by symptoms of systemic disturbance, such as fever, loss of
appetite, muscular pains and headache; and accompanied by concomitant
signs of the disease, such as enlargement of the lymphatic glands, sore
throat, mucous patches, falling of the hair and rheumatic pains.

#State the distinguishing characters of the late eruptions.#

The late eruptions (those following one or more years after the
contraction of the disease) are usually of tubercular, gummatous or
ulcerative type; are limited in extent, and have a marked tendency to
appear in circular, semicircular or crescentic forms or groups. Pain in
the bones, bone lesions and other symptoms may or may not be present.

#What is the color of syphilitic lesions?#

Usually, a dull brownish-red or ham-red, with at times a yellowish cast.

#Are there any subjective symptoms in syphilitic eruptions?#

As a rule, no; but in exceptional instances of the generalized
eruptions, more especially in negroes, there may be slight itching.

#Describe the macular, or erythematous, eruption of syphilis.#

The _macular syphiloderm_ is a general eruption, showing itself usually
six or eight weeks after the appearance of the chancre. It consists of
small or large, commonly pea- or bean-sized, rounded or
irregularly-shaped, not infrequently slightly rais