s.

#What is the prognosis?#

If the disease is recognized early, and properly treated, a cure may be
anticipated; later the outlook is that of scirrhus of the breast.

#What is the treatment of Paget's disease?#

Thorough cauterization by means of caustic potash or the
galvano-cautery; or, its extirpation by means of the curette or
excision. After extirpation or cauterization, supplementary treatment by
the _x_-ray is advisable as an additional measure of precaution against
relapse.

Until the diagnosis is thoroughly established, soothing applications,
such as are employed in acute eczema, are to be advised.

#Sarcoma.#
(_Synonyms:_ Sarcoma Cutis; Sarcoma of the Skin.)

#Describe the several varieties of sarcoma.#

Sarcoma of the skin is a more or less malignant new growth, of rapid or
slow progress, characterized by the appearance of single or multiple,
variously-shaped, discrete, non-pigmented or pigmented tubercles or
tumors, of size varying from that of a shot to a hazelnut or larger. As
a rule the growths are smooth, firm and elastic, somewhat painful upon
pressure, and exhibit a tendency to ulcerate. The overlying skin is at
first normal and somewhat movable, but as the growths approach the
surface it becomes reddened and adherent; or, if the disease is of the
pigmented variety, it acquires a bluish-black color. It is now generally
believed that the most of the pigmented cases formerly thought to be of
sarcomatous nature are really carcinomatous in character.

The multiple pigmented sarcoma (_melano-sarcoma_) appears first, usually
on the soles and dorsal surfaces of the feet, and later on the hands.
There is more or less diffuse thickening of the integument. The lesions
themselves manifest a disposition to bleed.

#State the prognosis and treatment of sarcoma.#

The disease is always more or less malignant and, as a rule, sooner or
later a fatal termination takes place. It is usually slow in its course.

Excision or extirpation, _x_-ray exposures, and the administration of
arsenic in increasing dosage (preferably by hypodermic injection) now
are generally considered the most promising in this usually hopeless
malady.

#Granuloma Fungoides.#

#Describe granuloma fungoides.#

A rare form of disease, heretofore looked upon as sarcomatous, but now
generally recognized as granuloma, and formerly described under the