e stomach, that is
taken in through the mouth. On one hand it may be that this is due to
the extremely small quantities necessary for an effect, on the other
hand and principally all the substances probably act only when they are
directly applied and brought in contact with the circulation of the
blood.

For a long time small syringes with fine needle points were used to
inject strong acting drugs under the skin. This is done in a measure to
have a guarantee of a sure effect which is not had by giving through
the mouth. For instance, it is known that emetics given through the
mouth often remain without results; if however the emetic apomorphine is
injected anywhere under the skin, vomiting surely follows within a very
short time. It is well known that morphine is injected under the skin in
preference to taking it through the mouth as its action as a pain killer
is much prompter.

Koch's liquid can also be injected under the skin with the aid of a
so-called Pravaz syringe. Koch uses a somewhat differently formed
syringe. The result remains the same, no matter what kind of syringe is
used.

At the same time it makes but little difference, on what part of the
body the injection is made, as the fluid injected under the skin is
distributed at once over the entire system. Koch chose the skin of the
back between the shoulderblades and the loins because here the injection
could be made without causing pain or inflammation.

The production of the liquid must be attended with great difficulties as
Koch plainly remarks that his stock at present is very limited and he
can only furnish larger quantities at the end of several weeks. The
price of a small bottle to be 25-30 Marks about 6-8 Dollars.

The human being is much more sensitive to Koch's remedy than the guinea
pig, which is commonly used for experiments of this kind. It seems that
no experiments have as yet been made with other animals.

Koch has tried the remedy on himself and has passed through all the
symptoms of a poisoning. He certainly injected into his arm a
considerable quantity of the liquid; twenty-five times as much as he
injected in his patients.

But here also there is a difference. In sick people much smaller
quantities act than in the healthy. One cubic centimeter of the liquid
has hardly any effect on a healthy person, but quite a marked one on
those afflicted with tuberculosis.

In the case of the latter one cubic centimeter produces about the same