ular attention to the further statements of Koch,
that through his remedy the tubercle bacilli are _not_ killed. With this
it is admitted that the remedy will not be able to effect cures, without
any more ado, yes, even the tubercle bacilli may continue to infect
parts of the body even in spite of the action of the remedy.

Therefore the application of Koch's remedy only, is not sufficient to
effect a cure. Provision must be made to remove the gangrenous tissue
from the body as rapidly as possible, because it contains the still
living tubercle bacilli. As a rule surgical aid is necessary to remove
the mortified tissue. Where this is impossible Koch advises the
continued application of the remedy to protect the endangered living
tissue from the re-immigration of the tubercle bacilli. Koch thereby
believes that he can protect the tissue, perhaps in the manner as
vaccination protects from small pox.

The rapid increase in the quantity of the remedy applied in the course
of time is something that has no parallel. Koch gives an explanation,
but leaves it to the future to be confirmed. We have no previous
instance in case that his explanation should prove correct. Reasoning
from analogous application of our remedy, we are led to assume that
_smaller_ quantities of the substance would suffice to cause
mortification of the remaining tuberculous tissue. Koch on the other
hand uses larger and larger doses to reach a result. He admits inurement
to the remedy within certain limits only.

Koch has made a difference between pulmonary consumptives and those
suffering from tuberculosis of the bones and joints, etc. He was able to
inject larger quantities in the latter than the former, for the quantity
injected in the case of pulmonary consumptives was .001 ccm.; in other
tuberculous cases .01 ccm.

Koch selected pulmonary consumptives for his experiments, whose sputum
contained tubercle bacilli, so as to make no error in the diagnosis, and
to ascertain by killing the bacilli contained in the sputum, whether the
diseased tend toward restoration. As the remedy does not kill the
bacilli, so a diminution of the bacilli can only be obtained in that
manner, that the tissue of the lungs undergoes certain changes, which
cause its properties to be such, that the bacilli are no longer able to
exist or propagate in them. Then a so-called immunity results which we
know of in other similar diseases. We know that anyone who has had the
measles o