symptoms as twenty-five times the quantity would in a healthy person.
The same must also be considered as symptoms of poisoning; but they are
only of short duration and are accompanied with magnificent success.

Of all diseases based on tuberculosis only ringworm or lupus is
perceivable by the eye, as it is a disease of the skin, all other
tuberculous diseases take their course in the internal parts of the
body, and therefore are not perceptible to the eye. The symptoms that
follow an injection of Koch's liquid can be best observed in the case of
lupus.

Koch therefore selected for his first illustration patients afflicted
with lupus that is ringworm. Even a few hours after the injection the
first perceptible changes begin to show in the diseased parts. These
begin to swell and redden; in other words an inflammation is caused,
through which the diseased tissue is obviously brought to mortification.
Soon the inflammation stops. The gangrenous tissue changes into crusts
or scabs which drop off in a short time and the patient is cured of his
ringworm.

Koch places particular importance on the fact that the inflammation is
restricted to the diseased parts only, and that it does not attack sound
and healthy parts. Even the smallest otherwise invisible knots are made
perceptible through the inflammation.

We have similar illustrations for this specific action of Koch's remedy
for lupus (ringworm). So for instance a syphilitic ulcer on the thigh
may be cured in a few days with iodide of potassium. In a similar
manner a morbidly enlarged spleen may be reduced to the normal size by
taking quinine.

The observation is very interesting indeed, as it may be shown whether a
person is tuberculous in any organ or not by the injection of .01 ccm.
In case he is tuberculous the poisoning symptoms appear in a marked
degree; if he is not, hardly any effect is noticeable.

Although we have had excellent methods for a long time to detect
pulmonary consumption, although Koch added the discovery of the tubercle
bacilli, it occasionally happens that the disease can not be recognized
in its beginning stages, because its progress is too slight. Now the
reaction following an injection is to be the deciding medium. Also with
other tuberculous affections physicians will welcome this diagnostic
auxiliary, for in the beginning of the same it often happens that no
certain diagnosis could be made and valuable time was lost.

We must call partic