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nious devices and by skillful manipulations, is as fascinating as any tale of adventure. When the microscope began its work, how discouraging was the vastness and complexity of the discoveries which it brought to light; how many years has it been diligently used, and how uncertain are we still about many of its revelations! But what a happy conjecture of man, and as proper environment takes place we may reach better results! Let me give an illustration: Some thirty years ago, Virchow began his studies and lectures upon cellular pathology. The enthusiasm which he awakened spread over the whole medical world. The wonderful attention to detail, the broad philosophy which signalized his observations, were alike remarkable. His class room was packed with students from every country, who thought it no hardship to struggle for a seat at eight o'clock in the morning. With his blackboard behind him and specimens of pathology before him, and microscopes coursing upon railway tracks around the tables which filled the room, he was the embodiment of the teacher; his highest honor was as discoverer. The life and importance of the cell, both in health and disease, it has been his work to discover and to teach. The point of view from which he has classified tumors is founded on this basis, and remains the accepted method. The light which he cast upon the nature of inflammation has not yet been obscured, and while other phenomena appear, the multiplication of cells and nuclei and the formation of connective tissue in the process of inflammation will always call to mind his labors. To one of Virchow's pupils, Prof. Recklinghausen, we chiefly owe our knowledge of the phenomena of diapedesis as a part of the inflammatory activity. How incredible it seems that masses of living matter can make their way through the walls of blood vessels which do not rupture and which have no visible apertures! Virchow fixed his attention upon the forms and activities of the cells, their multiplication and degradation, and how they build up tissues, both healthy and morbid. To another matter with which, both literally and metaphorically, the air is filled, we must also make allusion. The existence of micro-organisms in countless numbers is no new fact, but the influence they may exert over living tissues has only lately become the subject of earnest attention. So long as they were not known to have any practical bearing upon human welfare, they in
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