not absorbed at the inoculation points, nor do they disappear in
another way, but for a long time remain unchanged, and engender
greater or smaller suppurative foci. Anything, therefore, intended to
exercise a healing effect on the tuberculous process must be a soluble
substance which would be liberated to a certain extent by the fluids
of the body floating around the tubercle bacilli, and be transferred
in a fairly rapid manner to the juices of the body; while the
substance producing suppuration apparently remains behind in the
tubercular bacilli, or dissolves but very slowly. The only important
point was, therefore, to induce outside the body the process going on
inside, if possible, and to extract from the tubercular bacilli alone
the curative substance. This demanded time and toil, until I finally
succeeded, with the aid of a forty to fifty per cent. solution of
glycerine, in obtaining an effective substance from the tubercular
bacilli. With the fluid so obtained I made further experiments on
animals, and finally on human beings. These fluids were given to other
physicians to enable them to repeat the experiments.

The remedy which is used in the new treatment consists of a glycerine
extract, derived from the pure cultivation of tubercle bacilli. Into
the simple extract there naturally passes from the tubercular bacilli,
besides the effective substance, all the other matter soluble in fifty
per cent. glycerine.

Consequently, it contains a certain quantity of mineral salts,
coloring substances, and other unknown extractive matters. Some of
these substances can be removed from it tolerably easily. The
effective substance is insoluble in absolute alcohol. It can be
precipitated by it, though not, indeed, in a pure condition, but still
combined with the other extractive matter. It is likewise insoluble in
alcohol. The coloring matter may also be removed, rendering it
possible to obtain from the extract a colorless, dry substance
containing the effective principle in a much more concentrated form
than the original glycerine solution. For application in practice this
purification of the glycerine extract offers no advantage, because the
substances so eliminated are unessential for the human organism. The
process of purification would make the cost of the remedy
unnecessarily high.

Regarding the constitution of the more effective substances, only
surmises may for the present be expressed. It appears to me to be
deri