s even a cure has been established.
Standing quite by itself is the assertion that the remedy may not only
be dangerous in cases which have advanced too far--a fact which may
forthwith be conceded--but also that it actually promotes the
tuberculous process, being therefore injurious.

During the past six weeks I myself have had opportunity to bring
together further experiences touching the curative effects and
diagnostic application of the remedy in the cases of about one hundred
and fifty sufferers from tuberculosis of the most varied types in this
city and in the Moabit Hospital.

I can only say that everything I have latterly seen accords with my
previous observations. There has been nothing to modify in what I
before reported. As long as it was only a question of proving the
accuracy of my indications, it was needless for any one to know what
the remedy contained or whence it was derived. On the contrary,
subsequent testing would necessarily be more unbiased, the less people
knew of the remedy itself. Now, after sufficient confirmatory testing,
the importance of the remedy is proved, my next task is to extend my
study of the remedy beyond the field where it has hitherto been
applied, and if possible to apply the principle underlying the
discovery to other diseases.

This task naturally demands a full knowledge of the remedy. I
therefore consider that the time has arrived when the requisite
indications in this direction shall be made. This is done in what
follows.

Before going into the remedy itself, I deem it necessary for the
better understanding of its mode of operation to state briefly the way
by which I arrived at the discovery. If a healthy guinea pig be
inoculated with the pure cultivation of German Kultur of tubercle
bacilli, the wound caused by the inoculation mostly closes over with a
sticky matter, and appears in its early days to heal. Only after ten
to fourteen days a hard nodule presents itself, which, soon breaking,
forms an ulcerating sore, which continues until the animal dies. Quite
a different condition of things occurs when a guinea pig already
suffering from tuberculosis is inoculated. An animal successfully
inoculated from four to six weeks before is best adapted for this
purpose. In such an animal the small indentation assumes the same
sticky covering at the beginning, but no nodules form. On the
contrary, on the day following, or the second day after the
inoculation, the place where the