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tion, so there appears to be a connexion between integration of parts and sameness of function. * * * * * Closely related to the general truth that the evolution of all organisms is carried on by combined differentiations and integrations, is another general truth, which physiologists appear not to have recognized. When we look at the organic world as a whole, we may observe that, on passing from lower to higher forms, we pass to forms which are not only characterized by a greater differentiation of parts, but are at the same time more completely differentiated from the surrounding medium. This truth may be contemplated under various aspects. In the first place it is illustrated in _structure_. The advance from the homogeneous to the heterogeneous itself involves an increasing distinction from the inorganic world. In the lowest _Protozoa_, as some of the Rhizopods, we have a homogeneity approaching to that of air, water, or earth; and the ascent to organisms of greater and greater complexity of structure, is an ascent to organisms which are in that respect more strongly contrasted with the relatively structureless masses in the environment. In _form_ again we see the same truth. A general characteristic of inorganic matter is its indefiniteness of form, and this is also a characteristic of the lower organisms, as compared with the higher. Speaking generally, plants are less definite than animals, both in shape and size--admit of greater modifications from variations of position and nutrition. Among animals, the _Amoeba_ and its allies are not only almost structureless, but are amorphous; and the irregular form is constantly changing. Of the organisms resulting from the aggregation of amoeba-like creatures, we find that while some assume a certain definiteness of form, in their compound shells at least, others, as the Sponges, are irregular. In the Zoophytes and in the _Polyzoa_, we see compound organisms, most of which have modes of growth not more determinate than those of plants. But among the higher animals, we find not only that the mature shape of each species is quite definite, but that the individuals of each species differ very little in size. A parallel increase of contrast is seen in _chemical composition_. With but few exceptions, and those only partial ones, the lowest animal and vegetal forms are inhabitants of the water; and water is almost their sole constituent. D
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