of
inoculation for the Cow Pox. The matter was taken from a sore on the
hand of a dairymaid[1], who was infected by her master's cows, and it
was inserted, on the 14th of May, 1796, into the arm of the boy by
means of two superficial incisions, barely penetrating the cutis,
each about half an inch long.

[Illustration]

On the seventh day he complained of uneasiness in the axilla, and on
the ninth he became a little chilly, lost his appetite, and had a
slight head-ach. During the whole of this day he was perceptibly
indisposed, and spent the night with some degree of restlessness, but
on the day following he was perfectly well.

The appearance of the incisions in their progress to a state of
maturation were much the same as when produced in a similar manner by
variolous matter. The only difference which I perceived was, in the
state of the limpid fluid arising from the action of the virus, which
assumed rather a darker hue, and in that of the efflorescence
spreading round the incisions, which had more of an erysipelatous
look than we commonly perceive when variolous matter has been made
use of in the same manner; but the whole died away (leaving on the
inoculated parts scabs and subsequent eschars) without giving me or
my patient the least trouble.

In order to ascertain whether the boy, after feeling so slight an
affection of the system from the Cow-pox virus, was secure from the
contagion of the Small-pox, he was inoculated the 1st of July
following with variolous matter, immediately taken from a pustule.
Several slight punctures and incisions were made on both his arms,
and the matter was carefully inserted, but no disease followed. The
same appearances were observable on the arms as we commonly see when
a patient has had variolous matter applied, after having either the
Cow-pox or the Small-pox. Several months afterwards, he was again
inoculated with variolous matter, but no sensible effect was produced
on the constitution.

Here my researches were interrupted till the spring of the year 1798,
when from the wetness of the early part of the season, many of the
farmers' horses in this neighbourhood were affected with sore heels,
in consequence of which the Cow-pox broke out among several of our
dairies, which afforded me an opportunity of making further
observations upon this curious disease.

A mare, the property of a person who keeps a dairy in a neighbouring
parish, began to have sore heels the latter end