ce, so much resembled, on the
12th day, those appearing from the insertion of variolous matter,
that an experienced Inoculator would scarcely have discovered a shade
of difference at that period. Experience now tells me that almost the
only variation which follows consists in the pustulous fluids
remaining limpid nearly to the time of its total disappearance; and
not, as in the direct Small-pox, becoming purulent.--(See Plate, No.
4.)

_CASE XXII._

From the arm of this girl matter was taken and inserted April 12th
into the arms of John Marklove one year and a half old,

Robert F. Jenner, eleven months old,
Mary Pead, 5 years old, and
Mary James, 6 years old.

[Illustration]

Among these Robert F. Jenner did not receive the infection. The arms
of the other three inflamed properly and began to affect the system
in the usual manner; but being under some apprehensions from the
preceding Cases that a troublesome erysipelas might arise, I
determined on making an experiment with the view of cutting off its
source. Accordingly after the patients had felt an indisposition of
about twelve hours, I applied in two of these Cases out of the three,
on the vesicle formed by the virus, a little mild caustic, composed
of equal parts of quick-lime and soap, and suffered it to remain on
the part six hours[1]. It seemed to give the children but little
uneasiness, and effectually answered my intention in preventing the
appearance of erysipelas. Indeed it seemed to do more, for in half an
hour after its application, the indisposition of the children
ceased[2]. These precautions were perhaps unnecessary as the arm of
the third child, Mary Pead, which was suffered to take its common
course, scabbed quickly, without any erysipelas.

[Footnote 1: Perhaps a few touches with the lapis septicus would have
proved equally efficacious.]

[Footnote 2: What effect would a similar treatment produce in
inoculation for the Small-pox?]

_CASE XXIII._

From this child's arm matter was taken and transferred to that of J.
Barge, a boy of seven years old. He sickened on the 8th day, went
through the disease with the usual slight symptoms, and without any
inflammation on the arm beyond the common efflorescence surrounding
the pustule, an appearance so often seen in inoculated Small-pox.

After the many fruitless attempts to give the Small-pox to those who
had had the Cow-pox, it did not appear necessary, nor was it
convenie