nt to me, to inoculate the whole of those who had been the
subjects of these late trials; yet I thought it right to see the
effects of variolous matter on some of them, particularly William
Summers, the first of these patients who had been infected with
matter taken from the cow. He was therefore inoculated with variolous
matter from a fresh pustule; but, as in the preceding Cases, the
system did not feel the effects of it in the smallest degree. I had
an opportunity also of having this boy and William Pead inoculated by
my Nephew, Mr. Henry Jenner, whose report to me is as follows: "I
have inoculated Pead and Barge, two of the boys whom you lately
infected with the Cow-pox. On the 2d day the incisions were inflamed
and there was a pale inflammatory stain around them. On the 3d day
these appearances were still increasing and their arms itched
considerably. On the 4th day, the inflammation was evidently
subsiding, and on the 6th it was scarcely perceptible. No symptom of
indisposition followed.

To convince myself that the variolous matter made use of was in a
perfect state, I at the same time inoculated a patient with some of
it who never had gone through the Cow-pox, and it produced the
Small-pox in the usual regular manner."

These experiments afforded me much satisfaction, they proved that the
matter in passing from one human subject to another, through five
gradations, lost none of its original properties, J. Barge being the
fifth who received the infection successively from William Summers,
the boy to whom it was communicated from the cow.

* * * * *

I shall now conclude this Inquiry with some general observations on
the subject and on some others which are interwoven with it.

Although I presume it may be unnecessary to produce further testimony
in support of my assertion "that the Cow-pox protects the human
constitution from the infection of the Small-pox," yet it affords me
considerable satisfaction to say, that Lord Somerville, the President
of the Board of Agriculture, to whom this paper was shewn by Sir
Joseph Banks, has found upon inquiry that the statements were
confirmed by the concuring testimony of Mr. Dolland, a surgeon, who
resides in a dairy country remote from this, in which these
observations were made. With respect to the opinion adduced "that the
source of the infection is a peculiar morbid matter arising in the
horse," although I have not been able to prove it from act