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lus tuberculosis_, although there are varieties of this organism found in different species of animals that are sufficiently distinct to permit of recognition. The question of prime importance is, whether the bovine type is transmissible to the human or not. Artificial inoculation of cattle with tuberculous human sputum as well as pure cultures of this variety show that the human type is able to make but slight headway in cattle. This would indicate that the danger of cattle acquiring the infection from man would in all probability be very slight, but these experiments offer no answer as to the possibility of transmission from the bovine to the human. Manifestly it is impossible to solve this problem by direct experiment upon man except by artificial inoculation, but comparative experiments upon animals throw some light on the question. Theo. Smith[81] and others[82] have made parallel experiments with animals such as guinea pigs, rabbits and pigeons, inoculated with both bovine and human cultures of this organism. The results obtained in the case of all animals tested show that the virulence of the two types was much different, but that the bovine cultures were much more severe. While of course this does not prove that transmission from bovine to human is possible, still the importance of the fact must not be overlooked. In a number of cases record of accidental infection from cattle to man has been noted.[83] These have occurred with persons engaged in making post-mortem examinations on tuberculous animals, and the tubercular nature of the wound was proven in some cases by excision and inoculation. In addition to data of this sort that is practically experimental in character, there are also strong clinical reasons for considering that infection of human beings may occur through the medium of milk. Naturally such infection should produce intestinal tuberculosis, and it is noteworthy that this phase of the disease is quite common in children especially between the ages of two and five.[84] It is difficult to determine, though, whether primary infection occurred through the intestine, for, usually, other organs also become involved. In a considerable number of cases in which tubercular infection by the most common channel, inhalation, seems to be excluded, the evidence is strong that the disease was contracted through the medium of the milk, but it is always very difficult to exclude the possibility of pulmonary
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