manner of
fear and grief, as hereafter shall be declared.

SUBSECT. II.--_Of the part affected. Affection. Parties affected_.

Some difference I find amongst writers, about the principal part affected
in this disease, whether it be the brain, or heart, or some other member.
Most are of opinion that it is the brain: for being a kind of dotage, it
cannot otherwise be but that the brain must be affected, as a similar part,
be it by [1032]consent or essence, not in his ventricles, or any
obstructions in them, for then it would be an apoplexy, or epilepsy, as
[1033]Laurentius well observes, but in a cold, dry distemperature of it in
his substance, which is corrupt and become too cold, or too dry, or else
too hot, as in madmen, and such as are inclined to it: and this [1034]
Hippocrates confirms, Galen, the Arabians, and most of our new writers.
Marcus de Oddis (in a consultation of his, quoted by [1035]Hildesheim) and
five others there cited are of the contrary part; because fear and sorrow,
which are passions, be seated in the heart. But this objection is
sufficiently answered by [1036]Montaltus, who doth not deny that the heart
is affected (as [1037]Melanelius proves out of Galen) by reason of his
vicinity, and so is the midriff and many other parts. They do _compati_,
and have a fellow feeling by the law of nature: but forasmuch as this
malady is caused by precedent imagination, with the appetite, to whom
spirits obey, and are subject to those principal parts, the brain must
needs primarily be misaffected, as the seat of reason; and then the heart,
as the seat of affection. [1038]Capivaccius and Mercurialis have copiously
discussed this question, and both conclude the subject is the inner brain,
and from thence it is communicated to the heart and other inferior parts,
which sympathise and are much troubled, especially when it comes by
consent, and is caused by reason of the stomach, or _mirach_, as the
Arabians term it, whole body, liver, or [1039]spleen, which are seldom
free, pylorus, mesaraic veins, &c. For our body is like a clock, if one
wheel be amiss, all the rest are disordered; the whole fabric suffers: with
such admirable art and harmony is a man composed, such excellent
proportion, as Ludovicus Vives in his Fable of Man hath elegantly declared.

As many doubts almost arise about the [1040]affection, whether it be
imagination or reason alone, or both, Hercules de Saxonia proves it out of
Galen, Aetius, and Al