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iatromathematical, iatromechanical, or physiatric) was founded on theories of physiology, probably by Borelli, of Naples (1608-1679), although Sanctorius; Sanctorius, a professor at Padua, was a precursor, if not directly interested in establishing it. Sanctorius discovered the fact that an "insensible perspiration" is being given off by the body continually, and was amazed to find that loss of weight in this way far exceeded the loss of weight by all other excretions of the body combined. He made this discovery by means of a peculiar weighing-machine to which a chair was attached, and in which he spent most of his time. Very naturally he overestimated the importance of this discovery, but it was, nevertheless, of great value in pointing out the hygienic importance of the care of the skin. He also introduced a thermometer which he advocated as valuable in cases of fever, but the instrument was probably not his own invention, but borrowed from his friend Galileo. Harvey's discovery of the circulation of the blood laid the foundation of the Iatrophysical school by showing that this vital process was comparable to a hydraulic system. In his On the Motive of Animals, Borelli first attempted to account for the phenomena of life and diseases on these principles. The iatromechanics held that the great cause of disease is due to different states of elasticity of the solids of the body interfering with the movements of the fluids, which are themselves subject to changes in density, one or both of these conditions continuing to cause stagnation or congestion. The school thus founded by Borelli was the outcome of the unbounded enthusiasm, with its accompanying exaggeration of certain phenomena with the corresponding belittling of others that naturally follows such a revolutionary discovery as that of Harvey. Having such a founder as the brilliant Italian Borelli, it was given a sufficient impetus by his writings to carry it some distance before it finally collapsed. Some of the exaggerated mathematical calculations of Borelli himself are worth noting. Each heart-beat, as he calculated it, overcomes a resistance equal to one hundred and eighty thousand pounds;--the modern physiologist estimates its force at from five to nine ounces! THOMAS SYDENHAM But while the Continent was struggling with these illusive "systems," and dabbling in mystic theories that were to scarcely outlive the men who conceived them, there appeared in
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