"It causeth dryness of the brain, frenzy, dotage, and makes the body dry,
lean, hard, and ugly to behold," as [1569]Lemnius hath it. "The temperature
of the brain is corrupted by it, the humours adust, the eyes made to sink
into the head, choler increased, and the whole body inflamed:" and, as may
be added out of Galen, _3. de sanitate tuendo_, Avicenna _3. 1._ [1570]"It
overthrows the natural heat, it causeth crudities, hurts, concoction," and
what not? Not without good cause therefore Crato, _consil. 21. lib. 2_;
Hildesheim, _spicel. 2. de delir. et Mania_, Jacchinus, Arculanus on
Rhasis, Guianerius and Mercurialis, reckon up this overmuch waking as a
principal cause.

MEMB. III.

SUBSECT. I.--_Passions and Perturbations of the Mind, how they cause
Melancholy_.

As that gymnosophist in [1571]Plutarch made answer to Alexander (demanding
which spake best), Every one of his fellows did speak better than the
other: so may I say of these causes; to him that shall require which is the
greatest, every one is more grievous than other, and this of passion the
greatest of all. A most frequent and ordinary cause of melancholy, [1572]
_fulmen perturbationum_ (Picolomineus calls it) this thunder and lightning
of perturbation, which causeth such violent and speedy alterations in this
our microcosm, and many times subverts the good estate and temperature of
it. For as the body works upon the mind by his bad humours, troubling the
spirits, sending gross fumes into the brain, and so _per consequens_
disturbing the soul, and all the faculties of it,

[1573] ------"Corpus onustum,
Hesternis vitiis animum quoque praegravat una,"

with fear, sorrow, &c., which are ordinary symptoms of this disease: so on
the other side, the mind most effectually works upon the body, producing by
his passions and perturbations miraculous alterations, as melancholy,
despair, cruel diseases, and sometimes death itself. Insomuch that it is
most true which Plato saith in his Charmides, _omnia corporis mala ab anima
procedere_; all the [1574]mischiefs of the body proceed from the soul: and
Democritus in [1575]Plutarch urgeth, _Damnatam iri animam a corpore_, if
the body should in this behalf bring an action against the soul, surely the
soul would be cast and convicted, that by her supine negligence had caused
such inconveniences, having authority over the body, and using it for an
instrument, as a smith doth his hammer (saith [1576]Cyprian), impu