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rs to be usually manufactured from eugenol, a phenol contained in oil of cloves. Piperonal, an aldehyde closely allied to vanillin, is used in perfumery under the name of heliotropin and is prepared from oil of sassafras and oil of camphor. Cumarine, the material to which tonka bean, sweet woodruff, and new-mown hay owe their characteristic odors, was synthetically prepared by W.H. Parkin in 1868 by heating sodiosalicylic aldehyde with acetic anhydride, though now more cheaply prepared from an herb growing in Florida. Irone, which has the perfume of violets, was isolated in 1893 from a ketone contained in orris-root; and ionone, another ketone which has a very closely similar odor of fresh violets and was isolated after some years' further work, is largely used in the preparation of violet perfume. Irone and ionone are closely similar in composition to oil of turpentine which when taken into the body is partly converted into perfume and gives a strong odor of violets to the urine. "Little has yet been accomplished toward ascertaining the relation between the odor and the chemical constitution of substances in general. Hydrocarbons as a class possess considerable similarity in odor, so also do the organic sulphides and, to a much smaller extent, the ketones. The subject waits for some one to correlate its various physiological, psychological and physical aspects in the same way that Helmholtz did for sound. It seems, as yet, impossible to assign any probable reason to the fact that many substances have a pleasant odor. It may, however, be worth suggesting that certain compounds, such as the volatile sulphides and the indoles, have very unpleasant odors because they are normal constituents of mammalian excreta and of putrefied animal products; the repulsive odors may be simply necessary results of evolutionary processes." (_Loc. cit._, _Nature_, December 27, 1900.) Many of the perfumes in use are really combinations of a great many different odors in varying proportions, such as oil of rose, lavender oil, ylang-ylang, etc. The most highly appreciated perfumes are often made up of elements which in stronger proportion would be regarded as highly unpleasant. In the study and manufacture of perfumes Germany and France have taken the lead in recent times. The industry is
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