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he feces daily. Though they suffer from the effects of self-poisoning, yet they have no such well-defined symptoms of local disease and functional disturbance as are always found in those who have chronic constipation. Nevertheless, they have disturbances of practically all the functions of the system. Believing as they do that the evacuation of their bowels is complete, they are at a loss to find a cause for the toxemia (blood-poisoning), mal-nutrition, debility and general atony. The symptoms of auto-infection with the semi-constipated are as complex as with the severer cases, but not so well defined. The most prominent symptoms are those connected with the process of katabolism, that is, of degeneration of the tissues, as indicated by their color and texture. The liver, however, is usually held responsible for the bad complexion, impaired nutrition, constipation and diminished vitality, when really the liver is only indirectly concerned, as made manifest in the previous articles. The seat and source are found to be the diseased colon and rectum. Dr. Treves says: "The colon being the part of the bowel involved in obstruction due to fecal accumulation, it may be further assumed that the blocking of the gut will most usually concern its lower or terminal parts. Accumulation of feces is most common in the rectum and sigmoid flexure, and then in the cecum. Masses of feces may block the colon at any point, and more particularly at the flexures of the bowel. Still, the three common sites of the accumulation are those just named. The accumulation in the colon may assume the form of a more or less isolated nodule or mass. Thus a considerable lump may be found in the cecum or sigmoid flexure and the rest of the colon be comparatively clear of any gross accumulation. An isolated lump may even persist after free purgation. On the other hand, the accumulation may assume the form of several isolated fecal masses. One of them may occupy the cecum, another the transverse colon, and possibly a third the sigmoid flexure. The bowel between these masses may appear to be fairly clear." A number of the exciting causes of inflammation of the lower or terminal portion of the large intestine have been mentioned. It cannot, however, be too strongly emphasized that chronic inflammation of the colon and rectum results in hyperkinesis (excessive muscular irritability) and contra
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