d this suggestion was accepted by Dr. Reed and Dr. Lazear.
It became necessary for Dr. Reed to return to the United States and
the work was begun by Dr. Lazear, who applied infected mosquitoes
to a number of persons, himself included, without result. On the
afternoon of July 27, 1900, I submitted myself to the bite of an
infected mosquito applied by Dr. Lazear. The insect had been reared
and hatched in the laboratory, had been caused to feed upon four
cases of yellow fever, two of them severe, and two mild. The first
patient, a severe case, was bitten twelve days before; the second,
third and fourth patients had been bitten six, four and two days
previously, and were in character mild, severe and mild
respectively. In writing to Dr. Reed that night of the incident, I
remarked jokingly that if there was anything in the mosquito
theory, I should have a good dose. And so it happened. After having
slight premonitory symptoms for two days, I was taken sick on
August 31, and on September 1, I was carried to the yellow fever
camp. My life was in the balance for three days, and my chart shows
that on the fifth, sixth and seventh days my urine contained
eighth-tenths and nine-tenths of moist albumin. On the day I was
taken sick, August 31, 1900, Dr. Lazear applied the same mosquito,
with three others, to another individual who suffered a
comparatively mild attack and was well before I had left my bed. It
so happened that I was the first person in whom the mosquito was
proved to convey the disease.

"On the eighteenth of September, five days after I was permitted to
leave my bed, Dr. Lazear was stricken, and died in convulsions just
one week later, after several days of delirium with black vomit.
Such is yellow fever.

"He was bitten by a stray mosquito while applying the other insects
to a patient in one of the city hospitals. He did not recognize it
as a _Stegomyia_, and thought it was a _Culex_. It was permitted to
take its fill and he attached no importance to the bite until after
he was taken sick, when he related the incident to me. I shall
never forget the expression of alarm in his eyes when I last saw
him alive in the third or fourth day of his illness. The spasmodic
contractions of his diaphragm indicated that black vomit was
impending, and h