incidence of the fever was as follows: 8 showed it
only on admission; in 7 it was highest on admission but continued at a
low rate throughout the rest of the psychosis; in 5 it extended without
much variation throughout the psychosis; in 4 it appeared
intermittently, while in 2 it was accentuated during periods when the
mental symptoms were most pronounced. We see, then, that there is a
distinct tendency for the fever to be associated with the onset of the
disease.

When we look for other data from which we might discover causes for the
fever, we find less than we would like. The records are of observations
made, some of them, twenty years ago. Although the mental examinations
were careful, the records of the physical symptoms either were not made
or were lost in many cases. Consequently our description must be
tentative and is published merely to stimulate further research as cases
come to the attention of psychiatrists.

One looks, first, for other evidence of infection. Some of the cases
were thoroughly examined with modern methods and nothing whatever found.
Blood examinations were made in five cases; three of these had rather
high temperature with the following blood pictures: Charles O., 103
deg., leucocytosis of 23,000, with 91.5% polymorphonuclears; Annie G.
(Case 1), 103 deg., leucocytosis of 12,000 to 15,000, and 89%
polymorphonuclears; Caroline DeS. (Case 2), 104 deg., 15,000 leucocytes,
no differential made, Widal and diazo reaction negative. These three
cases, then, had marked febrile reactions and leucocytosis. It is quite
possible that they had infections which were not discovered. Of the
other two Rosie K. (Case 11) had a temperature of 100 deg. and 17,500
leucocytes associated with a fetid diarrhea, an unquestioned infection,
while Mary C. (Case 7), with a temperature of only 100 deg., had no rise
in number of total white cells but 41% of lymphocytes. This last might
be due to an internal secretion or an involuntary nervous system
anomaly. The possibility of the three high temperatures with
leucocytosis being due to intercurrent infections must be considered.
Charles O. had high fever only for ten days during a psychosis of
several months. Annie G.'s high fever was of about the same duration.
Caroline DeS. had short periods of marked pyrexia in the first and
seventh months of her long psychosis. Except for these episodes, these
three patients had the typical slight elevation of temperature. Three
case