e inflammation of the arm inoculated with variolous matter was
increasing fast, and he had the disease mildly at the usual time.

"Experiment 2d. I inoculated another child at the same time and in the same
manner, with blood taken on the first day of the eruption; but as the
appearance and effects were similar to those in the preceding experiment, I
shall not relate them minutely.

"Experiment 3d. October 20th. Blood was taken from a person who had the
small-pox, on the third day of the eruption, and on the sixth from the
commencement of the eruptive fever. I introduced some of it in its fluid
state into both arms of a boy seven years old.

21st. There appeared to be some inflammation under the cuticle, where the
punctures were made. 22d. Inflammation more considerable. 23d. On this day
the inflammation was somewhat greater, and the cuticle rather elevated.

"24th. Inflammation much less, and only a brown or orange-colour remained.
25th. Scarcely any discoloration left. On this day he was inoculated with
variolous matter, the progress of the infection went on in the usual way,
and he had the small-pox very favourably.

"At this time I was requested to inoculate a young person, who was thought
to have had the small-pox, but his parents were not quite certain; in one
arm I introduced variolous matter, and in the other blood, taken as in
experiment 3d. On the second day after the operation, the punctured parts
were inflamed, though I think the arm in which I had inserted variolous
matter was rather more so than the other. On the third the inflammation was
increased, and looked much the same as in the preceding experiment. 4th.
The inflammation was much diminished, and on the 5th almost gone. He was
exposed at the same time to the natural infection, but has continued
perfectly well.

"I have frequently observed (and believe most practitioners have done the
same), that if variolous matter be inserted in the arm of a person who has
previously had the small-pox, that the inflammation on the second or third
days is much greater, than if they had not had the disease, but on the
fourth or fifth it disappears.

"On the 23d I introduced blood into the arms of three more children, taken
on the third and fourth days of the eruption. The appearances were much the
same as mentioned in experiments first and third. They were afterwards
inoculated with variolous matter, and had the disease in the regular way.

"The above experiment