cur as slightly ovoid bodies 3 to 5 microns
long, which are somewhat pointed toward the poles, have a sharp double
contour, and only on artificial cultivation at a temperature of over 18 deg.
do they develop into the characteristic spore-carrying threads.

The period of incubation varies greatly, extending from three days to
four months, or even longer. In artificial inoculations with pus through
wounds in the skin, inflammation and swelling of the lymph vessels may
be noticed in ten to sixty days; these vessels show in their course a
development of hard nodules, from which abscesses form.

The natural infection without doubt is caused through superficial
wounds, such as galls, barbed-wire cuts, or through various stable
utensils, harness, bandages, insects, etc. Solipeds are mostly
susceptible, but cattle may also be infected.

_Symptoms._--The inflammation of the lymph vessels is usually first
observed on the extremities, especially on one or both hind legs; it may
also appear on the forelegs, shoulder, or neck, and more rarely on the
rump, udder, and scrotum. The lesions, as a rule, develop in the tissue
adjacent to the place of inoculation. In the early stages of the disease
the lymph vessels appear very hard and thickened, and along their course
hard nodules develop, ranging in size from a pea to a hen's egg. Later
these nodules soften, burst spontaneously, and discharge a thick,
yellowish pus. The surface of the resulting ulcers or abscess cavities
soon fills up with exuberant granulations which protrude beyond the
surface of the skin, giving it a fungoid appearance. The affected
extremities are considerably enlarged, similar to cases of simple
lymphangitis. In rare cases the mucous membrane of the nostrils may also
become affected, showing yellowish flat elevations and ulcerations, and
these may extend by metastasis to internal organs. In cases in which the
mucous membrane is affected, the submaxillary lymph gland may also
become enlarged and suppurate.

The constitutional symptoms accompanying this disease are not very
marked and may be altogether absent. There is usually only a very slight
fever, which seldom runs over 102 deg. F. The appetite is not impaired
except in the advanced cases.

_Lesions._--The anatomical changes are most marked in the skin and the
subcutaneous tissues. They may become 2 to 3 inches thick and indurated
as the result of fibrous-tissue formation, owing to the inflammation
present.