irregular intervals in numerous other States,
including Nebraska, Iowa, Montana, Wyoming, New Mexico, North Dakota,
and South Dakota.

_Symptoms._--There are many variations in the symptoms of dourine, and
this is particularly true of the disease as it occurs in this country.
Two distinct stages may be noted which vary somewhat from those
described in textbooks, but probably no more than could be expected when
differences of climatic conditions and methods of handling are taken
into consideration.

The first stage chiefly concerns the sexual organs and therefore differs
somewhat in the male and female. In the second stage the symptoms
indicating an affection of the nervous system are more prominent and are
not dependent upon the sex of the animal.

Following a variable period of incubation of from 8 days to 2 months,
there is seen in the stallion an irritation and swelling about the penis
and sheath. In a few days small vesicles or blisters may appear on the
penis, which later break, discharging a yellowish, serous fluid and
having irregular, raw ulcers. The ulcers show a tendency to heal
rapidly, leaving scars which are permanent. There may be more or less
continuous dripping from the urethra of a yellowish, serouslike fluid.
Stallions may show great excitement when brought in the vicinity of
mares, but service is often impossible because of the fact that a
complete erection of the penis does not occur.

In the mare the first symptoms may be so slight as to be overlooked. The
disease, being the result of copulation, usually begins with
inflammation of the vulva and vagina. There may be a mucopurulent
discharge, which may be slight or profuse in quantity, agglutinating the
hairs of the tail. The mare may appear uneasy and urinate frequently.
Vesicles may appear on the external vulva and mucous membrane of the
vulva and vagina which later rupture and form ulcers. On the dark skin
of the external vulva the scars resulting from healing of the ulcers are
white, more or less circular in outline, from one-eighth to half an inch
in diameter, and pitlike. This depigmentation of the skin about the
external genitals is permanent.

Urticarial eruptions or plaques which break out over various parts of
the body are a frequent symptom seen in animals of either sex. These are
sharply defined and edematous swellings of the skin about the size of a
half dollar or may be even larger. The usual locations of these plaques
are the cro