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ministered subcutaneously by means of a syringe, but the quantity of the vaccine to be injected and the number of doses to be used should be left to the judgment of a competent veterinarian. INFECTIOUS DISEASES. By RUSH SHIPPEN HUIDEKOPER, M. D., Vet. [Revised by A. Eichhorn, D. V. S.] GENERAL DISCUSSION. An infectious disease may be defined as any malady caused by the introduction into the body of minute organisms of the vegetable or animal kingdom which have the power to multiply indefinitely and set free certain peculiar poisons which are chiefly responsible for morbid changes. Nearly all diseases of animals for which a definite cause may be attributed are caused by bacteria; such are tuberculosis, anthrax, blackleg, lockjaw, and others. There are some diseases, as, for instance, Texas fever and rabies, which are caused by a minute animal parasite known as protozoa, while others again, like lumpy jaw and aspergillosis, are caused by fungi. Besides there are infectious diseases in which the causative agents have never been successfully isolated, as they are so small that they can not be detected by the aid of the most powerful microscope, and accordingly they are termed as ultravisible viruses. Hog cholera, foot-and-mouth disease, smallpox, and others belong to this group. Bacteria may be defined as very minute unicellular organisms of plantlike character. They multiply either by simple division or by spore formation, the latter usually taking place when the conditions pertaining to the growth of the bacteria become unfavorable. The spores are much more resistant to destruction than the bacteria which produce them. Another group of parasites producing disease is known as protozoa. These are more complex than bacteria, and their artificial cultivation is also much more difficult than is the case with the bacterial parasites. Of the representatives of this group, causing disease in animals, are the trypanosomes, which are the causative factors of dourine and surra, and the piroplasma, which induce Texas fever in cattle and malaria or biliary fever of horses. There are also disease-producing fungi which are responsible for certain affections in horses; among these the most important are mycotic lymphangitis, or sporotrichosis, and streptotrichosis. The introduction of the infection may take place in various ways. The most frequent method is by ingestion. Further, the entrance of the germs may
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