iral disease that interferes with the
functioning of the liver; most commonly spread through fecal
contamination of drinking water; victims exhibit jaundice, fatigue,
abdominal pain, and dark colored urine.

Typhoid fever - bacterial disease spread through contact with food or
water contaminated by fecal matter or sewage; victims exhibit sustained
high fevers; left untreated, mortality rates can reach 20%.

vectorborne diseases acquired through the bite of an infected
arthropod:

Malaria - caused by single-cell parasitic protozoa Plasmodium;
transmitted to humans via the bite of the female Anopheles mosquito;
parasites multiply in the liver attacking red blood cells resulting in
cycles of fever, chills, and sweats accompanied by anemia; death due to
damage to vital organs and interruption of blood supply to the brain;
endemic in 100, mostly tropical, countries with 90% of cases and the
majority of 1.5-2.5 million estimated annual deaths occurring in sub-
Saharan Africa.

Dengue fever - mosquito-borne (Aedes aegypti) viral disease associated
with urban environments; manifests as sudden onset of fever and severe
headache; occasionally produces shock and hemorrhage leading to death
in 5% of cases.

Yellow fever - mosquito-borne viral disease; severity ranges from
influenza-like symptoms to severe hepatitis and hemorrhagic fever;
occurs only in tropical South America and sub-Saharan Africa, where
most cases are reported; fatality rate is less than 20%.

Japanese Encephalitis - mosquito-borne (Culex tritaeniorhynchus) viral
disease associated with rural areas in Asia; acute encephalitis can
progress to paralysis, coma, and death; fatality rates 30%.

African Trypanosomiasis - caused by the parasitic protozoa Trypanosoma;
transmitted to humans via the bite of bloodsucking Tsetse flies;
infection leads to malaise and irregular fevers and, in advanced cases
when the parasites invade the central nervous system, coma and death;
endemic in 36 countries of sub-Saharan Africa; cattle and wild animals
act as reservoir hosts for the parasites.

Cutaneous Leishmaniasis - caused by the parasitic protozoa leishmania;
transmitted to humans via the bite of sandflies; results in skin
lesions that may become chronic; endemic in 88 countries; 90% of cases
occur in Iran, Afghanistan, Syria, Saudi Arabia, Brazil, and Peru; wild
and domesticated animals as well as humans can act as reservoirs of
infection.

Plague - bacterial disease