by the bowel of fairly large quantities of
physiologic salt solution in patients with glaucoma whose quantity of
urinary secretion was markedly below the normal, and in one or two
startling instances, which have been reported, achieved success in the
rapid reduction of the intra-ocular tension when by this technic the
urine secretion rose to the normal amount. To be sure, myotics were
also used, but these myotics were insufficient, totally so in the two
instances noted prior to the enteroclysis.

Very interesting are the observations on the subconjunctival injections
of various substances, notably the citrate of sodium, because of its
power of decreasing the affinity of ocular colloids for water. This
method of treating increased intra-ocular tension, introduced, as you
know, by Thomas and Fischer, has met with confirmation from a number of
sources in spite of the fact that Happe's experimental study failed to
confirm Fischer's observations; indeed, he even reports in several
instances a rise of tension.

As you will remember, the strength of ordinary crystallized sodium
citrate in water should be from 4.05 to 5.41 per cent. Of this five to
fifteen minims are injected, the eye having been previously cocainized
and adrenalinized. With frequent injections the weaker of the two
solutions is mixed with 2 to 4 parts of physiologic salt solution. These
authors in no sense claim to cure glaucoma, but to ameloriate it and
reduce the tension. Weekers has used the salts of calcium, 3 grams a
day, with success in so far as lowering of tension is concerned,
although it must be stated, as a reviewer of his work has said, that his
recommendation of this drug in these respects is poorly supported. On
the other hand, Tristiano seems to have proved that calcium chlorid is
capable of lowering ocular tension and clinically may be used as an
adjuvant in the treatment of glaucoma for this purpose, largely because
he believes that he has proven that it facilitates the absorption of
edema. Darier has reported that a single subconjunctival injection of a
milligram of iodate of sodium has cleared the cornea and lessened the
intra-ocular pain in glaucoma.

What shall be said in regard to certain medicinal agents which stimulate
the lymphagogue activity of the eyeball in their relation to the
reduction of intra-ocular tension, notably of dionin? Toczyski's
experiments with this drug on the normal eye indicate that it produces
first a rise of