of sinking the Patient, or that the
Disorder had continued for some Time, and the Paroxysms were distinct,
we seldom gave the Bark till the Violence of the Flux was abated: And
where-ever much Griping and Pain in the Bowels attended the Flux and
Ague, there Bleeding as well as Purgatives were necessary, before
exhibiting the Bark; which seldom or ever agreed with them, till there
was an evident _Apurexia_, or Absence of Fever in the Intervals
between the Fits. Where these Cautions were neglected, the Bark
generally made the Patients worse; and we were obliged to omit it,
till the Violence of the Purging was over.

Some Agues were accompanied with the Jaundice, though not in such a
high Degree as in the confirmed State of that Disorder; and commonly
in the Beginning the Pulse continued rather quick, in the Intervals
between the Paroxysms; and the Patients complained of some Degree of
Sickness for the first two or three Days. With those the Bark always
disagreed, till the Feverishness between the aguish Paroxysms was
gone; and we found, that the best Method of treating them, was to
bleed in the Beginning, if there was much Fever; and then to give a
Vomit and Purge, and to repeat them, if necessary; and where there was
no Purging, to give the saline Draughts, and other cooling Medicines;
and to add a few Grains of Rhubarb, or to give so much of the _pilulae
saponacae cum rheo_, daily, as procured one or two loose Stools.

After the Ague had regular Intermissions, and the Patient was quite
cool, and without Fever in the Intervals, if the Disorder did not
yield to the above Treatment, which it seldom did, we then gave the
Bark freely; even though the slight icteric Symptoms still remained;
and it put an End to the Ague, and removed the Jaundice at the same
Time, without the least Inconvenience to the Patient. In such Cases,
we generally used to add a few Grains of Rhubarb to the first Doses of
the Bark; or gave the Bark made up into Pills with Soap, and added
occasionally a few Grains of Rhubarb.

Several of those who had the icteric Symptoms along with the Ague, had
bilious Vomitings in the Time of the cold Fit; they found themselves
sick, with a bitter Taste in their Mouth, before the Approach of the
aguish Paroxysm; and many of them, though they took Emetics, which
operated freely at this Time, yet did not vomit up the Bile; but the
Sickness and bitter Taste continued till the cold Fit came on, when
they vomited Bile i