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children than in legitimate and more common in alcoholic mothers; there is an unfavorable environment of poverty in both cases, added to in the latter and usually in the former by the injurious action of the alcohol. The more extensive malformations have no effect on heredity, because the subjects of them are incapable of procreation. The malformations which arise from the accidents of pregnancy and which are compatible with a perfectly normal germ are in the nature of acquired characteristics and are not inherited. Those malformations, however, which are due to qualities in the germinal material itself are inherited, and certain of them with remarkable persistence. There are instances in which the slight malformation consisting in an excess of fingers or toes has persisted through many generations. It may occasionally lapse in a generation to reappear later. In certain cases, notably in the bleeders, the inheritance is transmitted by the female alone, in other cases by the sexes equally, but there are no cases of transmission by the male line only. It is evident that when the same malformation affects both the male and the female line the hereditary influence is much stronger. A case has been related to me in which most of the inhabitants in a remote mountain valley in Virginia where there has been much intermarriage have one of the joints of the fingers missing. There is a very prevalent idea that in close intermarriage in families variations and malformations often unfortunate for the individual are more common. All experimental evidence obtained by interbreeding of animals shows that close interbreeding is not productive of variation, but that variations existing in the breed become accentuated. Variations either advantageous or disadvantageous for the race or individual may either of them become more prevalent by close intermarriage. It seems, however, to have been shown by the customs of the human race that very close intermarriage is disadvantageous. Eugenics, which signifies an attempt at the betterment of the race by the avoidance of bad heredity, has within recent years attracted much attention and is of importance. Some of its advocates have become so enthusiastic as to believe that it will be possible to breed men as cattle and ultimately to produce a race ideally perfect. It is true that by careful selection and regulation of marriage certain variations, whether relating to coarse bodily form or to the
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