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longed disability and feeling of insecurity in the knee, is to be found in the wasting and loss of tone in the quadriceps extensor muscle; the feeling of insecurity is most marked in coming down stairs. The instability of the joint is often added to by stretching of the ligaments and lateral mobility. As a result of both of these factors the joint is liable to repeated slight strains or jars which irritate the synovial membrane and tend to keep up the effusion and excite the overgrowth of its tissue elements. TUBERCULOUS DISEASE While tuberculous disease of the knee is specially common in childhood and youth, it may occur at any period of life, and is not uncommon in patients over fifty. The disease originates in the synovial membrane and in the bones respectively with about equal frequency. When the synovial membrane is diseased, it tends to grow inwards over the articular surfaces (Fig. 122), shutting off the supra-patellar pouch and fixing the knee-cap to the femur, and diminishing the area of the articular surfaces. The ingrowth of synovial membrane may fill up the cavity of the joint, or may divide it up into compartments. Ulceration of the cartilage and caries of the articular surfaces are common accompaniments. [Illustration: FIG. 122.--Tuberculous Synovial Membrane of Knee, spreading over articular surface of femur.] The femur and tibia are affected with about equal frequency, and the nature and seat of the bone lesions are subject to wide variations. Multiple small foci may be found beneath the articular cartilage of the tibia, or along the margins of the femoral condyles--especially the medial. Caseating foci are comparatively rare, but they sometimes attain a considerable size--especially in the head of the tibia, where they may take the form of a caseous abscess. Sclerosed foci, which form sequestra, are comparatively common (Fig. 123). [Illustration: FIG. 123.--Lower End of Femur from an advanced case of Tuberculous Arthritis of the Knee. Towards the posterior aspect of the medial condyle there is a wedge-shaped sequestrum, of which the surface exposed to the joint is polished like porcelain. (Anatomical Museum, University of Edinburgh.)] #Clinical Types.#--(1) _Hydrops_ usually arises from a purely synovial lesion, but the joint may suddenly become distended with fluid when an osseous focus ruptures into the synovial cavity. It is met with chiefly in young adults. As the fluid accumul
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