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. JULIUS ROBERT MAYER was educated for D the medical profession. In the summer of 1840, as he himself informs us, he was at Java, and there observed that the venous blood of some of his patients had a singularly bright red colour. The observation riveted his attention; he reasoned upon it, and came to the conclusion that the brightness of the colour was due to the fact that a less amount of oxidation sufficed to keep up the temperature of the body in a hot climate than in a cold one. The darkness of the venous blood he regarded as the visible sign of the energy of the oxidation. It would be trivial to remark that accidents such as this, appealing to minds prepared for them, have often led to great discoveries. Mayer's attention was thereby drawn to the whole question of animal heat. Lavoisier had ascribed this heat to the oxidation of the food. 'One great principle,' says Mayer, 'of the physiological theory of combustion, is that under all circumstances the same amount of fuel yields, by its perfect combustion, the same amount of heat; that this law holds good even for vital processes; and that hence the living body, notwithstanding all its enigmas and wonders, is incompetent to generate heat out of nothing.' But beyond the power of generating internal heat, the animal organism can also generate heat outside of itself. A blacksmith, for example, by hammering can heat a nail, and a savage by friction can warm wood to its point of ignition. Now, unless we give up the physiological axiom that the living body cannot create heat out of nothing, 'we are driven,' says Mayer, 'to the conclusion that it is the total heat generated within and without that is to be regarded as the true calorific effect of the matter oxidised in the body.' From this, again, he inferred that the heat generated externally must stand in a fixed relation to the work expended in its production. For, supposing the organic processes to remain the same; if it were possible, by the mere alteration of the apparatus, to generate different amounts of heat by the same amount of work, it would follow that the oxidation of the same amount of material would sometimes yield a less, sometimes a greater, quantity of heat. 'Hence,' says Mayer, 'that a fixed relation subsists between heat and work, is a postulate of the physiological theory of combustion.' This is the simple and natural account, given subsequently by Mayer himself, of the course of though
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