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essful, and why it became lost is one of the mysteries of scientific research. It did remain lost until our own time.... I invented for the same purpose the ether spray process, in which a benumbing cold was produced by projecting a volatile liquid like ether or amylene, or a stream of compressed gas ... on the part to be anaesthetized. These methods have been so widely adopted that I need not enter into any description of them. I have merely to say that they were made without any aid of experiments of a painful kind on the lower animals.... The earliest experiment with ether spray was made on my own arm. --------------------- It is fortunate for me that I have been an eye-witness of the progress made in this department from its practical instauration. I recall the days when operations were performed without the aid either of general or local methods for abolishing pain. I have myself introduced new methods of anaesthesia, generally and locally; I have brought to trial a large number of new anaesthetics. By the invention of the lethal chamber I have had the delightful privilege of removing the taste and pain of death from probably a million of those friends of man, the faithful dogs. I write this not boastfully but truthfully.... Painful experiments have played no indispensible part in the discovery of anaesthesia. --------------------- It is a curious fact that every method of research which is most enduring, most intellectual and most free from moral evil is farthest away from any and every thing that shocks the conscience or raises a doubt as to necessity, in sensitive minds. If mathematics had to be cultivated through experiments on living animals, it would never have succeeded in unfolding the magnificent mysteries of the universe. The same applies to the work of the science of chemistry, of botany, and of physics generally. In my opinion, every man who studies natural things by experiments on living subjects of any species, feels the truth of what I am saying. I know in my own case, that my mind during such experiments has always been in a different state according to the line of experiment. When the experiment has been conducted on dead or inanimate matter, the return obtained from the labour demanded has always been not only satisfacdtory, but pleasant to the mind. On the contrary, when the experiment has been conducted on living or animate matter,
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