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ed by exercise, as well as the muscles. But when the action of the brain is feeble, and the blood in an impoverished condition, there is a greater tendency to the exudation of fluid; the substance of the brain is thereby softened, and serum, to the extent of one or more ounces, is frequently found in the ventricles, especially when the brain is much impaired by disease of its substance. In some cases of hydrocephalus pints of serum are effused, distending the brain and head enormously, and in many cases of insanity the ventricles and membranes of the brain are distended with serum. "Pritchard on Insanity" speaks of this distention of the ventricles, which were "very full of serum" in twenty-nine out of a hundred cases, and "in twenty-three ready to burst," and "in ten among twenty-four melancholies astonishingly distended." Dr. Spurzheim dissected a case of hydrocephalus, child of eighteen months, with two and a half pounds of water in the membranes of the brain; and James Cardinal, who died at the age of thirty years in London, had a pint of water in the lateral ventricles, and about nine pints between the brain and its membranes. BUSINESS DEPARTMENT. [Hand pointing right] _The first two numbers of the_ JOURNAL _were unavoidably delayed. The May number will appear in advance of the month._ The BUSINESS DEPARTMENT of the Journal deserves the attention of all its readers, as it will be devoted to matters of general interest and real value. The treatment of the opium habit by Dr. Hoffman is original and successful. Dr. Hoffman is one of the most gifted members of the medical profession. The electric apparatus of D. H. Fitch is that which I have found the most useful and satisfactory in my own practice. Mr. Fitch has recently perfected certain improvements in the Galvanic Battery, which enables him to furnish the best and cheapest which has ever been offered by any manufacturer. The _American Spectator_, edited by Dr. B. O. Flower, is conducted with ability and good taste, making an interesting family paper, containing valuable hygienic and medical instruction, at a remarkably low price. It is destined to have a very extensive circulation. I have written several essays in commendation of the treatment of disease by oxygen gas, and its three compounds, nitrous oxide, per-oxide and ozone. What is needed for its general introduction is a convenient portable apparatus. This is now furnished by Dr. B. M. Lawrence
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