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ing than it is with us. A great physiologist, well known among us, long ago expressed to me the same opinion; and one of the greatest of living naturalists, who is honored alike on both continents, is positive that brain-work is harder and more hurtful here than abroad, an opinion which is shared by Oliver Wendell Holmes and other competent observers. Certain it is that our thinkers of the classes named are apt to break down with what the doctor knows as cerebral exhaustion,--a condition in which the mental organs become more or less completely incapacitated for labor,--and that this state of things is very much less common among the savans of Europe. A share in the production of this evil may perhaps be due to certain general habits of life which fall with equal weight of mischief upon many classes of busy men, as I shall presently point out. Still, these will not altogether account for the fact, nor is it to my mind explained by any of the more obvious faults in our climate, nor yet by our habits of life, such as furnace-warmed houses, hasty meals, bad cooking, or neglect of exercise. Let a man live as he may, I believe he will still discover that mental labor is with us more exhausting than we could wish it to be. Why this is I cannot say, but it is not more mysterious than the fact that agents which, as sedatives or excitants, affect the great nerve-centres, do this very differently in different climates. There is some evidence to show that this is also the case with narcotics; and perhaps a partial explanation may be found in the manner in which the excretions are controlled by external temperatures, as well as by the fact which Dr. Brown-Sequard discovered, and which I have frequently corroborated, that many poisons are retarded in their action by placing the animal affected in a warm atmosphere. It is possible to drink with safety in England quantities of wine which here would be disagreeable in their first effect and perilous in their ultimate results. The Cuban who takes coffee enormously at home, and smokes endlessly, can do here neither the one nor the other to the same degree. And so also the amount of excitation from work which the brain will bear varies exceedingly with variations of climatic influences. We are all of us familiar with the fact that physical work is more or less exhausting in different climates, and as I am dealing, or about to deal, with the work of business men, which involves a certain
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