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malarious regions (as are all the alcoholics, beginning with wine) in quickening the circulation of the blood; may it, perhaps, also act as a preservative against light attacks of malaria? Possibly. But it is very certain that it possesses no efficacy in places where malaria is severe. It will suffice to prove this to recall the two epidemics of fever which afflicted the colony of the Tre Fontaine, near Rome, in 1880 and 1882. Everybody was attacked, and there were several cases of pernicious fever, although a good preparation of eucalyptus is manufactured in the place and is distributed largely to the colonists during the dangerous season of the year. ARSENIC FOR MALARIA. Having several times had occasion to observe, in malarious regions, that when recourse was had to arsenic in order to subdue fevers over which quinine had exerted almost no effect, relapses occurred but rarely; and having been able to satisfy myself that the arsenical treatment sometimes procured a permanent, immunity in individuals who are subject to frequent attacks of malaria, I began in 1880 to employ arsenic (arsenious acid) as a prophylactic in certain portions of the Roman Campagna. This remedy was indicated in an experiment of this sort, not only by reason of its durable anti-malarialae effects, but also by its low price, by the beneficial influence it exerts upon all the nutritive functions, and because it has no disagreeable taste and may therefore be given to everybody, even to children. My first trials in 1880 were rather encouraging, and I felt myself justified in engaging some proprietors and the association of our southern railroads to repeat the experiments on a large scale the following year, recommending them, however, to use arsenic in a solid form as offering an easy and certain dosage. This extensive prophylactic experiment began in 1881, and acquired constantly increasing proportions in 1882 and 1883, which have become still larger this year. An experiment of this kind is not easy to conduct in the beginning. The name, arsenic, frightens not only those whom we desire to submit to its action, but also the physicians, whose exaggerated fears have sometimes rendered the experiments of no avail, since they were conducted too timidly and the doses of arsenic employed were altogether insufficient. But some intelligent men, especially M. Ricchi, physician in chief to the southern railroads, were able speedily to triumph over these
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